We investigated how participants with collectivistic and individualistic orientation cope with social exclusion on a behavioral level. In Studies 1 and 2, we found participants with more individualistic orientation to indicate more antisocial behavioral intentions in response to exclusion than in response to inclusion; however, participants with more collectivistic orientation did not differ in their behavioral intentions between exclusion and inclusion. In the third and fourth study, we replicated our findings across cultures: German and U.S. participants indicated more antisocial and avoiding behavioral intentions under exclusion than under inclusion, whereas Turkish and Indian participants did not differ in their behavioral intentions between exclusion and inclusion. In Studies 3 and 4, only German and U.S. participants were significantly affected by exclusion, showing more negative mood, which correlated with their behavioral intentions. In Study 4, the different behavioral intentions of collectivists and individualists were mediated by a different threat experience. The findings emphasize the role of self-construal and culture, as well as the self-threat inherent in exclusion.