The question of whether religiosity is linked to prosocial behavior is currently hotly debated in psychology. This research contributes to this debate by showing that the nature of individuals’ religious orientations and their relationships to prosociality depend on their country’s social enforcement of religiosity. Our analyses of data from more than 70 countries indicate that in countries with no social pressure to follow a religion, religious individuals are more likely to endorse an intrinsic religious orientation (Study 1), engage in charity work (Study 2), disapprove of lying in their own interests (Study 3), and are less likely to engage in fraudulent behaviors (Study 4) compared with non-religious individuals. Ironically, in secular contexts, religious individuals are also more likely to condemn certain moral choices than non-religious individuals (Study 2). These effects of religiosity substantially weaken (and ultimately disappear) with increasing national levels of social enforcement of religiosity.