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Neuronal encoding of the switch from specific to generalized fear

December 1, 2014 by

Fear memories are crucial for survival. However, excessive generalization of such memories, characterized by a failure to discriminate dangerous from safe stimuli, is common in anxiety disorders. Researchers identified distinct neuronal populations in the amygdala that signaled generalized versus cue-specific associations and determined how their distributions switched during fear generalization. These results provide a cellular basis in the amygdala for the alteration of emotional states from normal to pathological fear.

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