Researchers have developed an intracellular recording device, a long three-dimensional nanoscale-tipped microneedle-electrodes. Moreover, they demonstrated the needle penetrations into muscle cells and measured the signals. The nanoelectrode, whose size is longer than the conventional intracellular nanoelectrode, has the potential to be used in cells that are deep within a tissue, such as cells in brain slices or brain in vivo, thus accelerating the understanding of the brain.