Can we empathize effectively with someone who has a different sensitivity to physical events from ours? Or, are we susceptible to an egocentric bias in overprojection, which may lead us to under- or overreact in such cases? In this study, participants with normal visual and auditory capacity observed a video clip in which a sighted or blind target was exposed to a strong flash or high-frequency sound, while their physiological arousals during the observation were recorded. On average, participants displayed a differential arousal pattern to the aversive stimuli, according to the target’s ability to perceive them. Degrees of arousal control were also correlated with dispositional differences in empathy. Participants who scored higher on the Empathic Concern subscale of Davis’s Interpersonal Reactivity Index were better at controlling arousals in accordance with the Target x Stimulus interaction. The authors’ findings have important implications for helping disabled people while respecting their inherent dignity and individual autonomy.