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Dopamine signals in primate brains

March 12, 2025 by

We're all familiar with Pavlovian conditioning, in which a reward-anticipatory behavior follows a reward-predicting stimulus. Perhaps you experience it yourself when passing a cafe or restaurant and catching a whiff of something delectable. Behind this mechanism is dopamine released within the striatum, the largest structure of the subcortical basal ganglia, which links motor movements and motivation. Yet it has remained unclear exactly what kind of dopamine signal is transmitted to the striatum to cause this behavior in primates. In order to understand this dopamine signal, a team of researchers developed a new method of monitoring dopamine, utilizing a fluorescent dopamine sensor.

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