The present research examines the role of allocations of losses versus gains on the emergence of unethical behavior as a function of people’s social value orientation. The authors demonstrate that (a) proselfs regard unethical behavior to prevent losses as more justified than prosocials (Study 1) and (b) proselfs engage in more unethical behavior to prevent losses than prosocials (Study 2). These differences are explained by prosocials’ greater concern for harm to interdependent others in the domain of losses. A third study further substantiates these findings by revealing that unethical behavior to prevent losses increases among prosocials as harm to others is reduced. In sum, these results reveal that depending on whether people attend only to their self-interest or also consider the outcomes of others, losses either may increase or curtail unethical conduct. Considering social value orientations thus may reconcile conflicting theoretical perspectives on the impact of losses on social decisions.