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Antidepressant usage linked to bipolar and mania

Evidence that the long-term use of antidepressants increases an individual’s risk of a future bipolar or manic phase is steadily mounting.

Ketamine and depression: too much too soon?

Preliminary studies into ketamine’s potential antidepressant effects look promising. A recently published editorial, however, adds a note of caution.

Depressed Pinterest users suffer from lack of positive messages, UGA study finds

Despite the large number of posts on visual social media platforms that suggest–and fuel–depressing or suicidal thoughts, there aren’t many for users to read and share that would help them cope…

No treatment difference between some antidepressants and behaviour therapy for severe depression

Both treatments should be made accessible to patients with major depressive disorder, experts advise.

Antidepressant with novel action appears safe and effective in phase 1b clinical trial

A small clinical trial of a novel antidepressant that stimulates neurogenesis – the production of new brain cells – shows that the compound appears to be safe and may be effective against depression.

Dads get baby blues, too

A new study shows that fathers as well as mothers can suffer from anxiety and depression around the birth of a new baby; around 1 in 10 men are affected.

Loneliness triggers cellular changes that can cause illness, study shows

Loneliness is more than a feeling: For older adults, perceived social isolation is a major health risk that can increase the risk of premature death by 14 percent.

Inflammation linked to weakened reward circuits in depression

Brain imaging shows distinctive aspects of high-inflammation depression.About one third of people with depression have high levels of inflammation markers in their blood.

Yin and yang of serotonin neurons in mood regulation

More nuanced view of brainstem neurons could lead to better drugs for depression and anxiety.

Online CBT unlikely to benefit patients with depression, study finds

Researchers assessing the effect of computerized cognitive behavioral therapy against depression conclude that the therapy offers little or no benefits.