Over the past decades, we have seen numerous tragic examples where the failure of institutions to meet the needs of infants for social contact and stimulation has led to the failure of these infants to thrive. Infancy and childhood are critical life periods that shape the development of the cortex. A generation of research suggests that enriched environments, full of interesting stimuli to explore, promote cortical development and cognitive function. In contrast, deprivation and stress may compromise cortical development and attenuate some cognitive functions.