By discovering a new mechanism that allows blood to enter the brain immediately after a stroke, researchers have opened the door to new therapies that may limit or prevent stroke-induced brain damage. A complex and devastating neurological condition, stroke is the fourth-leading cause of death and primary reason for disability in the U.S. The blood-brain barrier is severely damaged in a stroke and lets blood-borne material into the brain, causing the permanent deficits in movement and cognition seen in stroke patients.